Vitamin B12 injection / working resource
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A compounded vitamin B12 injection, with who it is for and what the trials show in plain view. What should I know about injection versus oral B12?
Open the Vitamin B12 library ↗A systematic review and meta-analysis states that vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue, that in most cases such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders, and that the effectiveness of vitamin B12 supplementation in such cases is uncertain.
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A systematic review and meta-analysis states that vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue, that in most cases such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders, and that the effectiveness of vitamin B12 supplementation in such cases is uncertain.
Supporting record ↗A randomized placebo-controlled trial in 95 IBS and IBD patients with deactivating fatigue and normal vitamin B12 blood levels gave 1000 μg vitamin B12 daily or placebo for 8 weeks, and the authors concluded that the study did not confirm the expected effect of non-conventional surplus vit B12 supplementation on fatigue.
Supporting record ↗A trial in thirty-one young Burmese men assessed physical performance capacity before and after injection of cyanocobalamin and a placebo, and found no significant difference between the 1 mg cyanocobalamin and placebo groups in any of the criteria measured.
Supporting record ↗A randomized placebo-controlled trial of methylcobalamin 1000 μg daily for 27 months in 271 diabetic outpatients aged 70 years or older with borderline vitamin B12 status concluded that vitamin B12 supplementation did not prevent cognitive decline.
Supporting record ↗A Cochrane review of oral versus intramuscular vitamin B12 for deficiency concluded that low quality evidence shows oral and IM vitamin B12 having similar effects in terms of normalising serum vitamin B12 levels, but oral treatment costs less, and it states that no trial reported on clinical signs and symptoms of vitamin B12 deficiency.
Supporting record ↗A scoping review of human studies concluded there is not sufficient evidence to assume that high plasma vitamin B12, high B12 intake, or treatment with pharmacological doses of vitamin B12, is causally related to cancer; a population-based observational cohort study found high cobalamin levels associated with the risk of subsequently diagnosed cancer.
Supporting record ↗FDA states that compounded drugs are not FDA-approved, which means that FDA does not verify the safety, effectiveness or quality of compounded drugs before they are marketed.
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